{"id":2102,"date":"2023-03-11T18:56:34","date_gmt":"2023-03-11T18:56:34","guid":{"rendered":"http:\/\/proboostnow.eu\/?page_id=2102"},"modified":"2024-07-18T16:49:18","modified_gmt":"2024-07-18T16:49:18","slug":"vakcinace","status":"publish","type":"page","link":"https:\/\/proboostnow.eu\/en_us\/vakcinace\/","title":{"rendered":"Vakcinace"},"content":{"rendered":"<div class=\"banner has-hover bg-zoom-fade\" id=\"banner-245588090\">\n          <div class=\"banner-inner fill\">\n        <div class=\"banner-bg fill\" >\n            <img loading=\"lazy\" decoding=\"async\" width=\"1020\" height=\"618\" src=\"https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/03\/medical-gbb4fbf347_1920-e1678561503761-1024x620.jpg\" class=\"bg attachment-large size-large\" alt=\"proboost o\u010dkov\u00e1n\u00ed\" \/>                                    \n                    <\/div>\n\t\t\n        <div class=\"banner-layers container\">\n            <div class=\"fill banner-link\"><\/div>            \n\n   <div id=\"text-box-1655592978\" class=\"text-box banner-layer x50 md-x50 lg-x50 y70 md-y70 lg-y70 res-text\">\n                                <div class=\"text-box-content text dark\">\n              \n              <div class=\"text-inner text-center\">\n                  \n\n\t<div id=\"text-757777843\" class=\"text\">\n\t\t\n\n<h3><strong>ProBoost posiluje \u00fa\u010dinnost vakcinace.<\/strong><\/h3>\n<h5>\u00a0<\/h5>\n<h5><strong>Vyvol\u00e1v\u00e1 n\u011bkolikan\u00e1sobn\u011b vy\u0161\u0161\u00ed a rychlej\u0161\u00ed protil\u00e1tkovou odpov\u011b\u010f.\u00a0<\/strong><\/h5>\n\t\t\n<style>\n#text-757777843 {\n  color: rgb(255, 255, 255);\n}\n#text-757777843 > * {\n  color: rgb(255, 255, 255);\n}\n<\/style>\n\t<\/div>\n\t\n\n              <\/div>\n           <\/div>\n                            \n<style>\n#text-box-1655592978 {\n  width: 84%;\n}\n#text-box-1655592978 .text-box-content {\n  font-size: 100%;\n}\n<\/style>\n    <\/div>\n \n\n        <\/div>\n      <\/div>\n\n            \n<style>\n#banner-245588090 {\n  padding-top: 500px;\n}\n<\/style>\n  <\/div>\n\n\n\t<div id=\"gap-1964832162\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1964832162 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n\n\t<div id=\"gap-696840044\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-696840044 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n\n\t<div id=\"gap-1750625065\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-1750625065 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n\n<div class=\"row\"  id=\"row-1542427970\">\n\n\n\t<div id=\"col-1969884263\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<div class=\"row\"  id=\"row-1159654214\">\n\n\n\t<div id=\"col-130753678\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n\t<div id=\"text-2813004719\" class=\"text\">\n\t\t\n\n<p>Thymov\u00fd protein A se pod\u00edl\u00ed na maturaci CD4+ T lymfocyt\u016f, kter\u00e9 hraj\u00ed z\u00e1sadn\u00ed \u00falohu p\u0159i indukci tvorby protil\u00e1tek stimulac\u00ed B lymfocyt\u016f.\u00a0<\/p>\n<p>B lymfocyty, kter\u00e9 jsou zodpov\u011bdn\u00e9 za tvorbu protil\u00e1tek \u010dekaj\u00ed na sign\u00e1l od CD4+Th lymfocyt\u016f. Teprve potom vyzr\u00e1vaj\u00ed a m\u011bn\u00ed se na bu\u0148ky produkuj\u00edc\u00ed protil\u00e1tky, tzv. imunoglobuliny. Protil\u00e1tky v podstat\u011b obal\u00ed bakterii nebo ciz\u00ed partikuli a t\u00edm usnadn\u00ed jej\u00ed pohlcen\u00ed fagocytuj\u00edc\u00edmi bu\u0148kami. Pro ty je takto l\u00e9pe \u201cstraviteln\u00e1\u201d a po jej\u00edm pohlcen\u00ed ji rozl\u00e1mou na men\u0161\u00ed kousky a spot\u0159ebuj\u00ed na svou v\u00fd\u017eivu. Kdy\u017e je infekce zdol\u00e1na, v\u011bt\u0161ina T a B bun\u011bk um\u00edr\u00e1. Z\u016fst\u00e1vaj\u00ed ale ty pam\u011b\u0165ov\u00e9, kter\u00e9 zajist\u00ed, \u017ee p\u0159i dal\u0161\u00edm kontaktu se stejn\u00fdm patogenem je reakce okam\u017eit\u00e1 a mnohon\u00e1sobn\u011b \u00fa\u010dinn\u011bj\u0161\u00ed a tak zabr\u00e1n\u00ed rozvinut\u00ed nemoci ji\u017e na po\u010d\u00e1tku.\u00a0<\/p>\n\t\t\n<style>\n#text-2813004719 {\n  color: rgb(0,0,0);\n}\n#text-2813004719 > * {\n  color: rgb(0,0,0);\n}\n<\/style>\n\t<\/div>\n\t\n<div class=\"row\"  id=\"row-963322420\">\n\n\n\t<div id=\"col-475934737\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n\t<div id=\"text-2161918969\" class=\"text\">\n\t\t\n\n<p>D\u00e1vkov\u00e1n\u00ed pro zlep\u0161en\u00ed odpov\u011bdi organismu na aplikaci vakc\u00edn je 1-2 mcg TPA bez ohledu na hmotnost zv\u00ed\u0159ete.<\/p>\n<p>Vakcinovat lze pouze zdrav\u00e1 zv\u00ed\u0159ata. Z tohoto d\u016fvodu je vhodn\u00e9 pod\u00e1vat ProBoost alespo\u0148 t\u00fdden p\u0159ed pl\u00e1novanou aplikac\u00ed vakc\u00edny a pro zlep\u0161en\u00ed jej\u00edho efektu je\u0161t\u011b alespo\u0148 t\u0159i n\u00e1sleduj\u00edc\u00ed t\u00fddny.\u00a0\u00a0<\/p>\n\t\t\n<style>\n#text-2161918969 {\n  color: rgb(0,0,0);\n}\n#text-2161918969 > * {\n  color: rgb(0,0,0);\n}\n<\/style>\n\t<\/div>\n\t\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n<\/div>\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n<\/div>\n<div class=\"row\"  id=\"row-927150541\">\n\n\n\t<div id=\"col-665064829\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<div class=\"row\"  id=\"row-402776138\">\n\n\n\t<div id=\"col-1786780455\" class=\"col small-12 large-12\"  >\n\t\t\t\t<div class=\"col-inner text-center\"  >\n\t\t\t\n\t\t\t\n\n\t<div id=\"gap-163912983\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-163912983 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n\n\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_865847412\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"517\" height=\"650\" src=\"https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945.png 517w, https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945-510x641.png 510w, https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945-239x300.png 239w, https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945-10x12.png 10w, https:\/\/proboostnow.eu\/wp-content\/uploads\/2023\/02\/Screenshot-2023-02-01-191945-500x629.png 500w\" sizes=\"auto, (max-width: 517px) 100vw, 517px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_865847412 {\n  width: 50%;\n}\n<\/style>\n\t<\/div>\n\t\n\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n<\/div>\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\n<style>\n#row-927150541 > .col > .col-inner {\n  background-color: rgb(217, 217, 221);\n}\n<\/style>\n<\/div>\n\t<div id=\"text-3765723790\" class=\"text\">\n\t\t\n\n<p>Bylo prok\u00e1z\u00e1no, \u017ee u ps\u016f TPA zesiluje protil\u00e1tkov\u00e9 reakce na virus vztekliny nejm\u00e9n\u011b p\u011btin\u00e1sobn\u011b. Na grafu \u010d. 3 je zn\u00e1zorn\u011bn \u00fa\u010dinek TPA na titry protil\u00e1tek proti viru vztekliny u ps\u016f o\u010dkovan\u00fdch vakc\u00ednou s usmrcen\u00fdm virem vztekliny. V kontroln\u00ed skupin\u011b, kter\u00e1 byla o\u010dkov\u00e1na vakc\u00ednou usmrcen\u00fdm virem vztekliny potencovanou hlin\u00edkem, dos\u00e1hly titry protil\u00e1tek proti viru vztekliny vrcholu b\u011bhem dvou t\u00fddn\u016f na \u00farovni v\u00fdrazn\u011b pod 250. Zv\u00ed\u0159ata v experiment\u00e1ln\u00ed skupin\u011b vykazovala p\u0159etrv\u00e1vaj\u00edc\u00ed zv\u00fd\u0161en\u00e9 titry, kter\u00e9 dos\u00e1hly vrcholu asi dva t\u00fddny po imunizaci, na \u00farovni p\u0159esahuj\u00edc\u00ed 750.<\/p>\n<p>Ve druh\u00e9m modelu pou\u017eit\u00e9m k testov\u00e1n\u00ed \u00fa\u010dinnosti TPA byli psi imunizov\u00e1ni virulentn\u00edm virem psinky plus adjuvans bu\u010f hlin\u00edk nebo TPA. O virech psinky (Morbillivirus) je zn\u00e1mo, \u017ee maj\u00ed imunosupresivn\u00ed \u00fa\u010dinky. \u00da\u010dinnost vakcinace s TPA byla v\u00edce ne\u017e dvojn\u00e1sobn\u00e1.<\/p>\n<p>U my\u0161\u00ed je prim\u00e1rn\u00ed ochrana, stejn\u011b jako u lid\u00ed, zaji\u0161t\u011bna zv\u00fd\u0161en\u00fdmi titry protil\u00e1tek proti hemaglutininov\u00e9mu antigenu (HA). V prim\u00e1rn\u00ed reakci na infekci ch\u0159ipkou byly titry HA u my\u0161\u00ed zv\u00fd\u0161eny 8kr\u00e1t. Titry byly 1:20 u mlad\u00fdch my\u0161\u00ed inokulovan\u00fdch samotn\u00fdm virem a 1:160 u my\u0161\u00ed dost\u00e1vaj\u00edc\u00edch virov\u00e9 inokulace plus TPA. Bu\u0148kou zprost\u0159edkovan\u00e1 odpov\u011b\u010f na ch\u0159ipkov\u00fd virus je rozhoduj\u00edc\u00ed pro zotaven\u00ed z infekce. To je d\u016fle\u017eit\u00e9, proto\u017ee \u201ebun\u011b\u010dn\u00e1 imunitn\u00ed odpov\u011b\u010f \u2013 cell-mediated immune (CMI) response\u201c je zam\u011b\u0159ena na vysoce konzervativn\u00ed, nestruktur\u00e1ln\u00ed genov\u00fd produkt exprimovan\u00fd na infikovan\u00fdch bu\u0148k\u00e1ch, kter\u00fd je spole\u010dn\u00fd v\u0161em zn\u00e1m\u00fdm kmen\u016fm ch\u0159ipky A. Pokud se tedy jedinec nakaz\u00ed ch\u0159ipkou kv\u016fli genetick\u00e9 variabilit\u011b molekuly HA, r\u00e1zn\u011bj\u0161\u00ed reakce CMI by mohla velmi dob\u0159e zkr\u00e1tit dobu trv\u00e1n\u00ed nemoci, proto\u017ee \u201epam\u011b\u0165ov\u00e1\u201c CMI by byla zk\u0159\u00ed\u017een\u011b reaktivn\u00ed se v\u0161emi ch\u0159ipkov\u00fdmi kmeny.<\/p>\n<p>Za \u00fa\u010delem testov\u00e1n\u00ed t\u00e9to mo\u017enosti byly my\u0161i, kter\u00e9 byly infikov\u00e1ny ch\u0159ipkou s nebo bez TPA , testov\u00e1ny za n\u011bkolik t\u00fddn\u016f na jejich sekund\u00e1rn\u00ed cytotoxickou \u201ekiller\u201c bun\u011b\u010dnou odpov\u011b\u010f proti c\u00edlov\u00fdm bu\u0148k\u00e1m infikovan\u00fdm virem ch\u0159ipky. Aktivita zab\u00edjen\u00ed m\u011b\u0159en\u00e1 l\u00fdzou c\u00edlov\u00fdch bun\u011bk byla zv\u00fd\u0161ena nejm\u00e9n\u011b 9kr\u00e1t u lymfocyt\u016f od p\u0159\u00edjemc\u016f TPA<\/p>\n\t\t\n<style>\n#text-3765723790 {\n  color: rgb(0,0,0);\n}\n#text-3765723790 > * {\n  color: rgb(0,0,0);\n}\n<\/style>\n\t<\/div>\n\t\n<p>Zdroj: https:\/\/patents.google.com\/patent\/US5616554A\/en<\/p>\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2102","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/pages\/2102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/comments?post=2102"}],"version-history":[{"count":0,"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/pages\/2102\/revisions"}],"wp:attachment":[{"href":"https:\/\/proboostnow.eu\/en_us\/wp-json\/wp\/v2\/media?parent=2102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}